The OHSU Knight Cancer Institute is a pioneer in personalized cancer treatment and research, where the development of Gleevec transformed Chronic Myeloid Leukemia from a fatal disease to a manageable one and proved that targeted therapies can work. The institute focuses on precision oncology, the early detection, prevention, and treatment of cancer, and creating a welcoming and supportive environment for its caregivers, researchers, and support personnel. Knight affiliates subscribe to three guiding principles: we are bold, we are supportive, and we work as a connected team in our fight to end cancer as we know it. We’d love for you to join us!
Every Knight Cancer employee is expected to embody our guiding principles:
We are seeking a highly motivated candidate with a strong mathematical background to fill a part-time, hourly position for a Computational Biologist 1 on the Reactome Project Team with Dr. Guanming Wu. This interdisciplinary role offers an exciting opportunity to work at the intersection of computational biology, bioinformatics, and applied mathematics (including statistical modeling and machine learning), in close collaboration with a leading wet-lab research team, Dr. Ted Braun’s group at the Knight Cancer Institute. The project focuses on developing multimodal AI/LLM-based models to predict the progression of aggressive myeloproliferative neoplasms (aMPN) to acute myeloid leukemia (AML). The successful candidate will be assisting with single-cell data analysis, developing machine learning (ML) and deep learning (DL) approaches for integrative pathway and network modeling with clinical variables, and applying AI technologies to build domain-specific knowledge graphs using Reactome’s pathway knowledgebase. The position requires a strong foundation in mathematics (e.g., linear algebra, probability, and optimization) and the ability to apply these concepts to complex biological data.
Reactome is a leading open-source knowledgebase of human biological pathways. It provides tools for pathway curation, visualization, and enrichment analysis, serving the global research community. The Reactome project team is dedicated to integrating cutting-edge computational methods, including AI and ML, to continuously improve its offerings for large-scale data analysis and pathway-based research. The new team member will be working with Dr. Guanming Wu’s team, one of four organizations of the Reactome international consortium.
Duties include:
Apply online. Please be sure to upload a Cover Letter and Resume/CV.
We offer a variety of benefits on top of joining a thriving organization:
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We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact askhr@ohsu.edu
