Work Location: Los Angeles, CA, USA
Onsite or Remote
Fully On-Site
Work Schedule
Monday – Friday, 8:00am – 5:00pm
Posted Date
12/29/2025
Salary Range $105700 - 234500 Annually
Employment Type
2 - Staff: Career
Duration
Indefinite
Job #
27905
The Molecular Diagnostics Laboratory is seeking an experienced Variant Scientist to join our clinical team. In this critical role, you will curate and interpret germline and somatic variants and prepare high-quality clinical reports derived from exome and targeted cancer sequencing assays. You will contribute to variant classification, test development efforts, and clinical research projects that advance precision medicine for patients across UCLA Health and beyond. Primary duties include:
•Review and assess patient clinical notes and sequencing data from high-complexity molecular assays, including Clinical Exome Sequencing, Solid Tumor Sequencing Panels, and Hematologic Malignancy Sequencing Panels.
•Perform variant curation and interpretation using established guidelines and evidence-based resources.
•Draft and refine clinical reports, ensuring accuracy, clarity, and clinical relevance.
•Develop and update SOPs for variant curation, interpretation, and reclassification workflows
•Participate in submitting curated variants to public databases (e.g. ClinVar) and contribute to quality improvement and test development initiatives.
•Collaborate with clinicians, genetic counselors, and laboratory staff to support accurate and timely reporting.
•Contribute to clinical research projects and assist in implementing new molecular diagnostic assays.
Salary Range: $105,700.00 - $234,500.00/year
•At least two years’ experience in germline variant curation is required. Somatic variant curation experience is a plus.•Strong working knowledge of laboratory genetics and genomics, including target capture, amplification, and massively parallel sequencing.•Familiarity with widely used genomic tools such as IGV and UCSC/COSMIC genome browsers•Ability to establish effective working relationships with clinicians, genetic counselors, and other team members.•Programming or bioinformatics experience (e.g. R, SAS, Perl, Python, regex, database design) – preferred.•PhD in human genetics, molecular genetics, cancer biology, or a related discipline – preferred. Master’s degree in molecular biology, genetics, or a closely related field may be considered with relevant experience.
For more than half a century, UCLA Health has provided the best in healthcare and the latest in medical technology to the people of Los Angeles and throughout the world.
Comprised of Ronald Reagan UCLA Medical Center, UCLA Medical Center Santa Monica, Resnick Neuropsychiatric Hospital at UCLA, UCLA Mattel Children's Hospital, UCLA West Valley Medical Center and the UCLA Medical Group with its wide-reaching system of primary-care and specialty-care offices throughout the region, UCLA Health is among the most comprehensive and advanced healthcare systems in the world.
Our physicians are world leaders in the diagnosis and treatment of complex illnesses, and our hospitals are among the best in the country. Consistently ranked one of the top ten hospitals in the nation and the best medical center in the western United States by U.S. News & World Report, Ronald Reagan UCLA Medical Center is at the cutting edge of biomedical research, and our doctors and scientists are leaders in performing pioneering work across an astounding range of disciplines, from organ transplantation and cardiac surgery to neurosurgery and cancer treatment, and bringing the latest discoveries to virtually every field of medicine.
