Job Description

At GeneDx (Nasdaq: WGS), we don’t just diagnose rare diseases — we redefine what’s possible in precision medicine. With one of the world’s largest, rare disease datasets, we turn genomic data into answers that change lives and accelerate discovery. Patients and families around the world are counting on us to lead with bold ideas, relentless focus, and drive to end the diagnostic odyssey.  Visit www.genedx.com to learn how we’re making precision medicine the global standard of care. 

The Associate Clinical Analyst II (ABMGG-eligible or active candidate) supports the interpretation of genetic findings and contributes to accurate diagnosis and case resolution through exome and genome sequencing. This entry-level role focuses on building foundational clinical analysis skills by assisting with case reviews under supervision, performing routine data interpretation tasks. Responsibilities include supporting variant classification activities, preparing accurate documentation, and contributing to internal database updates. The Associate Clinical Analyst II ensures timely documentation, maintains quality standards, and aids departmental initiatives through collaborative engagement and continuous learning.

Shift: Tuesday-Saturday or Sunday-Thursday 9am-5pm ET

How to Apply: Please submit your resume along with a cover letter (required for consideration) detailing your experience and motivation for applying. Applications without a cover letter will not be considered.

Job Responsibilities

• Perform clinical data analysis and case management to accurately interpret genetic findings.

• Establish phenotype-genotype correlations across diverse genetic disorders.

• Investigate and interpret clinical features of genetic conditions using internal resources and professional tools.

• Review and finalize genetic test reports, interpret variants, and curate internal databases.

• Serve as a subject matter expert for designated genes, disorders, tests, and workflows.

• Communicate with clients via email, phone, or other channels to support case resolution and provider engagement.

• May abstract clinical information from patient records.

• Performs literature reviews and database searches to support variant interpretation and classification.

• Meets or exceeds productivity and error standards as assigned by team lead.

• Documents evidence and rationale for variant classification in a clear, standardized format.

• Assist with development of variant-, gene-, or disease-specific test information and report language.

• Perform other duties as assigned to support the team or department.

• Credential-specific responsibilities include but are not limited to: 

• ABMGG Certified: Fulfill responsibilities of  Clinical Consultant as defined by CLIA (42 CFR 493.1457), including: 

• Consultation Availability: Provides timely consultation to ordering providers regarding test selection, interpretation, and clinical correlation of laboratory results. 

• Report Oversight: Reviews and ensures laboratory reports meet CLIA and CAP requirements for accuracy, completeness, and clinical relevance. 
• Result Authorization: Approves and signs off on high-complexity test results in accordance with CLIA regulations. 

Education, Experience, and Skills

• PhD in Biology, Genetics or related field, MD or DO with more than 2 years directly relevant experience in clinical diagnostics (including fellowship)

• Excellent verbal and written communication skills

• Demonstrated computer skills, including ability to maintain high proficiency with internal systems and Microsoft Office Suite and the Office 365 environment

• Prior experience with variant curation is preferred but not required

Certificates, Licenses, Registrations

• ABMGG certification or equivalent, certified in at least one specialty OR board eligible

Physical Demands

• Prolonged periods of sitting or working at a computer in a home office environment

• Occasional need to lift or move materials or equipment weighing up to 20 pounds during travel or team visits

Work Environment

• Frequent use of digital communication platforms (e.g. video conferencing, email, and collaboration tools).

• Ability to focus and manage complex tasks in a remote setting with multiple concurrent priorities.

• May require occasional travel to laboratory sites, corporate offices, or conferences (typically <10%).

#LI-REMOTE

Pay Transparency, Budgeted Range $150,000—$165,000 USD

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Science - Minded, Patient - Focused.

At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care.

Experts in what matters most.

With hundreds of genetic counselors, MD/PhD scientists, and clinical and molecular genomics specialists on staff, we are the industry’s genetic testing experts and proud of it. We share the same goal as healthcare providers, patients, and families: to provide clear, accurate, and meaningful answers we all can trust.

SEQUENCING HAS THE POWER TO SOLVE DIAGNOSTIC CHALLENGES.

From sequencing to reporting and beyond, our technical and clinical experts are providing guidance every step of the way:

TECHNICAL EXPERTISE

• High-quality testing Our laboratory is CLIA certified and CAP accredited and most of our tests are also New York State approved.
• Advanced detection By interrogating genes for complex variants, we can identify the underlying causes of conditions that may otherwise be missed.

CLINICAL EXPERTISE

• Thorough analysis We classify variants according to our custom adaptation of the most recent guidelines. We then leverage our rich internal database for additional interpretation evidence.
• Customized care Our experts review all test results and write reports in a clear, concise, and personalized way. We also include information for research studies in specific clinical situations.
• Impactful discovery Our researchers continue working to find answers even after testing is complete. Through both internal research efforts and global collaborations, we have identified and published hundreds of new disease-gene relationships and developed novel tools for genomic data analysis. These efforts ultimately deliver more diagnostic findings to individuals.

Learn more About Us here

Our Culture

At GeneDx, we are dedicated to cultivating an environment where creativity and innovation thrive. We believe in the power of community and collaboration, where diverse perspectives are embraced, and every voice contributes to our shared success. Our team is a vibrant mix of professionals who challenge and support each other in equal measure, fostering growth both personally and professionally. When you join us, you're not just taking on a job—you're joining a movement. A movement that champions curiosity, embraces change, and believes in making an impact, one patient at a time. Cultural principles we live by:  

• Be bold in our vision & brave in our execution. 
• Communicate directly, with empathy. 
• Do what we say we're going to do.  
• Be adaptable to change.  
• Operate with a bias for action.  

Benefits include:

• Paid Time Off (PTO)
• Health, Dental, Vision and Life insurance
• 401k Retirement Savings Plan
• Employee Discounts
• Voluntary benefits

GeneDx is an Equal Opportunity Employer.

All privacy policy information can be found here